Toll-like receptor 4 signal transduction in platelets: novel pathways
نویسندگان
چکیده
منابع مشابه
Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4.
An understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort to provide a molecular basis for the lethal effect of LPS during septic shock and point the way to novel therapies. Rapid progress in this field during the last 6 years has resulted in the discovery of not only the receptor for LPS - Toll-like receptor 4 (TLR4) - but also in a better appreciation of the...
متن کاملPlatelets express functional Toll-like receptor-4.
Profound thrombocytopenia occurs in humans with sepsis and in mice administered lipopolysaccharide (LPS). Growing evidence indicates that platelets may contribute to these abnormalities, but whether that is a direct result of LPS activation of platelets or an indirect result of other inflammatory mechanisms remains unclear. Here we demonstrate that although platelets do not increase P-selectin ...
متن کاملMicrobial strategies for antagonizing Toll-like-Receptor signal transduction
Within a few years of the discovery of Toll-like receptors (TLRs) and their role in innate immunity, viral and bacterial proteins were recognized to antagonize TLR signal transduction. Since then, as TLR signaling networks were unraveled, microbial systems have been discovered that target nearly every component within these pathways. However, recent findings as well as some notable exceptions p...
متن کاملToll-like receptor 4 signalling: new perspectives on a complex signal-transduction problem.
We previously reported that Toll-like receptor-2 (TLR2) agonists induce expression of a more limited repertoire of pro-inflammatory genes than TLR4 agonists. Murine macrophages stimulated with the TLR4 agonist, Escherichia coli lipopolysaccharide, induced signal transducer and activator of transcription 1 ('STAT1') tyrosine phosphorylation that was secondary to the autocrine/paracrine action of...
متن کاملThe myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistance domain-containing adaptor to be described that participates in Toll-like receptor (TLR) signaling. TRAM functions exclusively in the TLR4 pathway. Here we show by confocal microscopy that TRAM is localized in the plasma membrane and the Golgi apparatus, where it colocalizes with TLR4. Membrane localization of TRAM is the re...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2010
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2010.08292.x